A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin

A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin

Gastric cancer remains a serious health burden with few therapeutic options. Therefore, the recognition of cancer stem cells (CSCs) as seeds of the tumorigenic process makes them a prime therapeutic target. Knowing that the transcription factors SOX2 and OCT4 promote stemness, our approach was to is...

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Bibliographic Details
Main Authors: Diana Pádua, Rita Barros, Ana Luísa Amaral, Patrícia Mesquita, Ana Filipa Freire, Mafalda Sousa, André Filipe Maia, Inês Caiado, Hugo Fernandes, António Pombinho, Carlos Filipe Pereira, Raquel Almeida
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
cancer stem cells
gastric cancer
sox2
monensin
sore6-gfp reporter system
drug resistance
high-throughput screening
Online Access:https://www.mdpi.com/2072-6694/12/2/495

Internet

https://www.mdpi.com/2072-6694/12/2/495

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