Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation

Growing evidence suggests a major role for Src-homology-2-domain-containing phosphatase 2 (SHP2/PTPN11) in MYCN-driven high-risk neuroblastoma, although biologic confirmation and a plausible mechanism for this contribution are lacking. Using a zebrafish model of MYCN-overexpressing neuroblastoma, we...

Full description

Bibliographic Details
Main Authors: Xiaoling Zhang, Zhiwei Dong, Cheng Zhang, Choong Yong Ung, Shuning He, Ting Tao, Andre M. Oliveira, Alexander Meves, Baoan Ji, A. Thomas Look, Hu Li, Benjamin G. Neel, Shizhen Zhu
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
neuroblastoma
zebrafish
Gab2
Shp2
ptpn11
RAS-ERK pathway
MYCN
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302802

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717302802

Similar Items