Enhanced Expression of Anti-CD19 Chimeric Antigen Receptor in piggyBac Transposon-Engineered T Cells

Enhanced Expression of Anti-CD19 Chimeric Antigen Receptor in piggyBac Transposon-Engineered T Cells

Adoptive T cell therapy using chimeric antigen receptor (CAR)-modified T cells is a promising cancer immunotherapy. We previously developed a non-viral method of gene transfer into T cells using a piggyBac transposon system to improve the cost-effectiveness of CAR-T cell therapy. Here, we have furth...

Full description

Bibliographic Details
Main Authors: Daisuke Morita, Nobuhiro Nishio, Shoji Saito, Miyuki Tanaka, Nozomu Kawashima, Yusuke Okuno, Satoshi Suzuki, Kazuyuki Matsuda, Yasuhiro Maeda, Matthew H. Wilson, Gianpietro Dotti, Cliona M. Rooney, Yoshiyuki Takahashi, Yozo Nakazawa
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
chimeric antigen receptor
non-viral vector
piggyBac
transposon
virus-specific antigens
acute lymphoblastic leukemia
refractory
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117301286

Internet

http://www.sciencedirect.com/science/article/pii/S2329050117301286

Similar Items