Select G-Protein-Coupled Receptors Modulate Agonist-Induced Signaling via a ROCK, LIMK, and β-Arrestin 1 Pathway

Select G-Protein-Coupled Receptors Modulate Agonist-Induced Signaling via a ROCK, LIMK, and β-Arrestin 1 Pathway

G-protein-coupled receptors (GPCRs) are typically present in a basal, inactive state but, when bound to an agonist, activate downstream signaling cascades. In studying arrestin regulation of opioid receptors in dorsal root ganglia (DRG) neurons, we find that agonists of delta opioid receptors (δORs...

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Bibliographic Details
Main Authors: Nitish Mittal, Kristofer Roberts, Katsuri Pal, Laurent A. Bentolila, Elissa Fultz, Ani Minasyan, Catherine Cahill, Amynah Pradhan, David Conner, Kathryn DeFea, Christopher Evans, Wendy Walwyn
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713005998

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http://www.sciencedirect.com/science/article/pii/S2211124713005998

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