Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism

Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism

Microglia are brain immune cells responsible for immune surveillance. Microglial activation is, however, closely associated with neuroinflammation, neurodegeneration, and obesity. Therefore, it is critical that microglial immune response appropriately adapts to different stressors. The circadian clo...

Full description

Bibliographic Details
Main Authors: Xiao-Lan Wang, Samantha E. C. Wolff, Nikita Korpel, Irina Milanova, Cristina Sandu, Patrick C. N. Rensen, Sander Kooijman, Jean-Christophe Cassel, Andries Kalsbeek, Anne-Laurence Boutillier, Chun-Xia Yi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
inflammation
palmitic acid
cellular metabolism
oxidative stress
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.586399/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.586399/full

Similar Items