Chromosome organization by one-sided and two-sided loop extrusion

Chromosome organization by one-sided and two-sided loop extrusion

SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and progressively growing DNA loops. Modeling assuming two-sided loop extrusion reproduces key features of chromatin organization acros...

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Bibliographic Details
Main Authors: Edward J Banigan, Aafke A van den Berg, Hugo B Brandão, John F Marko, Leonid A Mirny
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
loop extrusion
cohesin
condensin
chromosome organization
mitosis
TADs
Online Access:https://elifesciences.org/articles/53558

Internet

https://elifesciences.org/articles/53558

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