The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease

The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease

Abstract Hypoxia is prevalent in atherosclerotic plaques, promoting plaque aggravation and subsequent cardiovascular disease (CVD). Transmembrane protein carbonic anhydrase IX (CAIX) is hypoxia-induced and can be shed into the circulation as soluble CAIX (sCAIX). As plaque macrophages are hypoxic, w...

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Main Authors: J. A. F. Demandt, L. J. Dubois, K. van Kuijk, M. Zaťovičová, H. Jin, S. Parkkila, S. W. van der Laan, L. Jelenska, B. M. E. Mees, C. P. M. Reutelingsperger, K. B. J. M. Cleutjens, C. J. H. van der Kallen, C. G. Schalkwijk, M. M. J. van Greevenbroek, E. A. L. Biessen, G. Pasterkamp, S. Pastoreková, C. D. A. Stehouwer, J. C. Sluimer
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79978-5

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https://doi.org/10.1038/s41598-020-79978-5

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