Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution

Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution

Abstract Double-strand breaks (DSBs) result from the attack of both DNA strands by multiple sources, including radiation and chemicals. DSBs can cause the abnormal chromosomal rearrangements associated with cancer. Recent techniques allow the genome-wide mapping of DSBs at high resolution, enabling...

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Bibliographic Details
Main Authors: Raphaël Mourad, Krzysztof Ginalski, Gaëlle Legube, Olivier Cuvier
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Genome Biology
Subjects:
Double-strand breaks
Epigenetics
Chromatin
Machine learning
Online Access:http://link.springer.com/article/10.1186/s13059-018-1411-7

Internet

http://link.springer.com/article/10.1186/s13059-018-1411-7

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