The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells

The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells

Abstract Objective Patients with systemic lupus erythematosus (SLE) have an ongoing interferon (IFN) production due to an activation of plasmacytoid dendritic cells (pDCs), which can be triggered to type I IFN synthesis by RNA containing immune complexes (RNA-IC). Considering emerging data suggestin...

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Bibliographic Details
Main Authors: Karin Hjorton, Niklas Hagberg, Pascal Pucholt, Maija-Leena Eloranta, Lars Rönnblom
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Arthritis Research & Therapy
Subjects:
SLE
IFN
pDC
NK
HCQ
IRAK4
Online Access:http://link.springer.com/article/10.1186/s13075-020-02186-z

Internet

http://link.springer.com/article/10.1186/s13075-020-02186-z

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