Computational design of thermostabilizing point mutations for G protein-coupled receptors

Computational design of thermostabilizing point mutations for G protein-coupled receptors

Engineering of GPCR constructs with improved thermostability is a key for successful structural and biochemical studies of this transmembrane protein family, targeted by 40% of all therapeutic drugs. Here we introduce a comprehensive computational approach to effective prediction of stabilizing muta...

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Bibliographic Details
Main Authors: Petr Popov, Yao Peng, Ling Shen, Raymond C Stevens, Vadim Cherezov, Zhi-Jie Liu, Vsevolod Katritch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
GPCR
stabilizing mutations
machine learning
Online Access:https://elifesciences.org/articles/34729

Internet

https://elifesciences.org/articles/34729

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