Calcium Dobesilate Restores Autophagy by Inhibiting the VEGF/PI3K/AKT/mTOR Signaling Pathway

Calcium Dobesilate Restores Autophagy by Inhibiting the VEGF/PI3K/AKT/mTOR Signaling Pathway

Objective: Calcium dobesilate (CaD), an effective drug for the treatment of diabetic microvascular complications, especially diabetic retinopathy, is widely used in the clinic. Interestingly, several studies have indicated that CaD is therapeutic for diabetic kidney disease (DKD). Recently, evidence...

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Bibliographic Details
Main Authors: Yue Wang, Yun-hong Lu, Chao Tang, Mei Xue, Xiao-yu Li, Yun-peng Chang, Ying Cheng, Ting Li, Xiao-chen Yu, Bei Sun, Chun-jun Li, Li-ming Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
diabetic kidney disease
calcium dobesilate
autophagy
albuminuria
VEGF
VEGFR2
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00886/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00886/full

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