A Germline-Encoded Structural Arginine Trap Underlies the Anti-DNA Reactivity of a Murine V Gene Segment

A Germline-Encoded Structural Arginine Trap Underlies the Anti-DNA Reactivity of a Murine V Gene Segment

Autoimmunity may have its origins of early repertoire selection in developmental B cells. Such a primary repertoire is probably shaped by selecting B cells that can efficiently perform productive signaling, stimulated by self-antigens in the bone marrow, such as DNA. In support of that idea, we prev...

Full description

Bibliographic Details
Main Authors: Ronny Petterson dos Santos Araújo, Renato Kaylan Alves França, Napoleão Fonseca Valadares, Andrea Queiroz Maranhão, Marcelo Macedo Brigido
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
V genes
anti-DNA
pre-BCR
autoreactivity
B cell’s repertoire
Online Access:https://www.mdpi.com/1422-0067/22/9/4541

Internet

https://www.mdpi.com/1422-0067/22/9/4541

Similar Items