A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

Vaccines that interrupt malaria transmission will be important tools for malaria elimination. Here the authors identify a human monoclonal antibody from Pfs230 vaccinated individuals that blocks transmission of Plasmodium falciparum to mosquitoes in a complement-dependent manner and reacts with game...

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Bibliographic Details
Main Authors: Camila H. Coelho, Wai Kwan Tang, Martin Burkhardt, Jacob D. Galson, Olga Muratova, Nichole D. Salinas, Thiago Luiz Alves e Silva, Karine Reiter, Nicholas J. MacDonald, Vu Nguyen, Raul Herrera, Richard Shimp, David L. Narum, Miranda Byrne-Steele, Wenjing Pan, Xiaohong Hou, Brittany Brown, Mary Eisenhower, Jian Han, Bethany J. Jenkins, Justin Y. A. Doritchamou, Margery G. Smelkinson, Joel Vega-Rodríguez, Johannes Trück, Justin J. Taylor, Issaka Sagara, Jonathan P. Renn, Niraj H. Tolia, Patrick E. Duffy
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21955-1

Internet

https://doi.org/10.1038/s41467-021-21955-1

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