Long-Term Aspartame Administration Leads to Fibrosis, Inflammasome Activation, and Gluconeogenesis Impairment in the Liver of Mice

Long-Term Aspartame Administration Leads to Fibrosis, Inflammasome Activation, and Gluconeogenesis Impairment in the Liver of Mice

Background: Aspartame is an artificial sweetener used in foods and beverages worldwide. However, it is linked to oxidative stress, inflammation, and liver damage through mechanisms that are not fully elucidated yet. This work aimed to investigate the effects of long-term administration of aspartame...

Full description

Bibliographic Details
Main Authors: Isabela A. Finamor, Caroline A. Bressan, Isabel Torres-Cuevas, Sergio Rius-Pérez, Marcelo da Veiga, Maria I. Rocha, Maria A. Pavanato, Salvador Pérez
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biology
Subjects:
aspartame
liver fibrosis
lipid peroxidation
Nrf2
inflammasome
PGC-1α
Online Access:https://www.mdpi.com/2079-7737/10/2/82

Internet

https://www.mdpi.com/2079-7737/10/2/82

Similar Items