Direct, acute effects of Klotho and FGF23 on vascular smooth muscle and endothelium.

Direct, acute effects of Klotho and FGF23 on vascular smooth muscle and endothelium.

Chronic kidney disease (CKD) is regarded as a state of Klotho deficiency and FGF23 excess. In patients with CKD a strong association has been found between increased serum FGF23 and mortality risk, possibly via enhanced atherosclerosis, vascular stiffness, and vascular calcification. The aim of this...

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Bibliographic Details
Main Authors: Isabelle Six, Hirokazu Okazaki, Priscilla Gross, Joanna Cagnard, Cédric Boudot, Julien Maizel, Tilman B Drueke, Ziad A Massy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24695641/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24695641/?tool=EBI

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