Differential Profile of Systemic Extracellular Vesicles From Sporadic and Familial Alzheimer’s Disease Leads to Neuroglial and Endothelial Cell Degeneration

Differential Profile of Systemic Extracellular Vesicles From Sporadic and Familial Alzheimer’s Disease Leads to Neuroglial and Endothelial Cell Degeneration

Evidence suggests that extracellular vesicles (EVs) act as mediators and biomarkers of neurodegenerative diseases. Two distinct forms of Alzheimer disease (AD) are known: a late-onset sporadic form (SAD) and an early-onset familial form (FAD). Recently, neurovascular dysfunction and altered systemic...

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Bibliographic Details
Main Authors: Juan Villar-Vesga, Julián Henao-Restrepo, Daniëlle C. Voshart, David Aguillon, Andrés Villegas, Diana Castaño, Julián D. Arias-Londoño, Inge S. Zuhorn, Laís Ribovski, Lara Barazzuol, Gloria P. Cardona-Gómez, Rafael Posada-Duque
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
extracellular vesicle
proteomic analyses
platelet
endothelium
organoids
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2020.587989/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2020.587989/full

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