Sulfated dextrans enhance in vitro amplification of bovine spongiform encephalopathy PrP(Sc) and enable ultrasensitive detection of bovine PrP(Sc).

Sulfated dextrans enhance in vitro amplification of bovine spongiform encephalopathy PrP(Sc) and enable ultrasensitive detection of bovine PrP(Sc).

Prions, infectious agents associated with prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy (BSE) in cattle, and scrapie in sheep and goats, are primarily comprised of PrP(Sc), a protease-resistant misfolded isoform of the cellular prion protein PrP(C). Pro...

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Main Authors: Yuichi Murayama, Miyako Yoshioka, Kentaro Masujin, Hiroyuki Okada, Yoshifumi Iwamaru, Morikazu Imamura, Yuichi Matsuura, Shigeo Fukuda, Sadao Onoe, Takashi Yokoyama, Shirou Mohri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2949392?pdf=render

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http://europepmc.org/articles/PMC2949392?pdf=render

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