Dendritic Cell-Based Immunotherapy in Advanced Sarcoma and Neuroblastoma Pediatric Patients: Anti-cancer Treatment Preceding Monocyte Harvest Impairs the Immunostimulatory and Antigen-Presenting Behavior of DCs and Manufacturing Process Outcome

Dendritic Cell-Based Immunotherapy in Advanced Sarcoma and Neuroblastoma Pediatric Patients: Anti-cancer Treatment Preceding Monocyte Harvest Impairs the Immunostimulatory and Antigen-Presenting Behavior of DCs and Manufacturing Process Outcome

Despite efforts to develop novel treatment strategies, refractory and relapsing sarcoma, and high-risk neuroblastoma continue to have poor prognoses and limited overall survival. Monocyte-derived dendritic cell (DC)-based anti-cancer immunotherapy represents a promising treatment modality in these n...

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Bibliographic Details
Main Authors: Eva Hlavackova, Katerina Pilatova, Dasa Cerna, Iveta Selingerova, Peter Mudry, Pavel Mazanek, Lenka Fedorova, Jana Merhautova, Lucie Jureckova, Lukas Semerad, Rita Pacasova, Lucie Flajsarova, Lenka Souckova, Regina Demlova, Jaroslav Sterba, Dalibor Valik, Lenka Zdrazilova-Dubska
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
dendritic cells
anti-cancer medications
sarcoma
neuroblastoma
cell-based medicinal products
investigator-initiated clinical trial
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01034/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01034/full

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