Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects

Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects

Abstract Wnt signaling plays a major role in early neural development. An aberrant activation in Wnt/β-catenin pathway causes defective anteroposterior patterning, which results in neural tube closure defects (NTDs). Changes in folate metabolism may participate in early embryo fate determination. We...

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Bibliographic Details
Main Authors: Jianting Li, Qiu Xie, Jun Gao, Fang Wang, Yihua Bao, Lihua Wu, Lihong Yang, Zhizhen Liu, Rui Guo, Ajab Khan, Dan Liu, Caihua Li, Jianxin Wu, Jun Xie
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03313-z

Internet

https://doi.org/10.1038/s41419-020-03313-z

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