2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitros⃞

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitros⃞

Pharmacologic approaches to studying palmitoylation are limited by the lack of specific inhibitors. Recently, screens have revealed five chemical classes of small molecules that inhibit cellular processes associated with palmitoylation (Ducker, C. E., L. K. Griffel, R. A. Smith, S. N. Keller, Y. Zhu...

Full description

Bibliographic Details
Main Authors: Benjamin C. Jennings, Marissa J. Nadolski, Yiping Ling, Meredith Beckham Baker, Marietta L. Harrison, Robert J. Deschenes, Maurine E. Linder
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Journal of Lipid Research
Subjects:
DHHC, Asp-His-His-Cys
lipidation
fatty acylation
S-acylation
enzyme
inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520414476

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520414476

Similar Items