IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus

IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA) is a major hospital- and community-acquired pathogen, but the mechanisms underlying host-defense to MRSA remain poorly understood. Here, we investigated the role of IL-21 in this process. When administered intra-tracheally into wild-type mice, IL-21...

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Bibliographic Details
Main Authors: Rosanne Spolski, Erin E West, Peng Li, Sharon Veenbergen, Sunny Yung, Majid Kazemian, Jangsuk Oh, Zu-Xi Yu, Alexandra F Freeman, Stephen M Holland, Philip M Murphy, Warren J Leonard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
methicillin-resistant Staph aureus
IL-21
neutrophil
Online Access:https://elifesciences.org/articles/45501

Internet

https://elifesciences.org/articles/45501

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