ER Stress is Involved in Epithelial-To-Mesenchymal Transition of Alveolar Epithelial Cells Exposed to a Hypoxic Microenvironment

ER Stress is Involved in Epithelial-To-Mesenchymal Transition of Alveolar Epithelial Cells Exposed to a Hypoxic Microenvironment

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal interstitial lung disease of unknown origin. Alveolar epithelial cells (AECs) play an important role in the fibrotic process as they undergo sustained endoplasmic reticulum (ER) stress, and may acquire a mesenchymal...

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Bibliographic Details
Main Authors: Eva Delbrel, Yurdagül Uzunhan, Abdoulaye Soumare, Thomas Gille, Dominique Marchant, Carole Planès, Emilie Boncoeur
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
ER stress
alveolar epithelial cell
loss of phenotype
Online Access:http://www.mdpi.com/1422-0067/20/6/1299

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http://www.mdpi.com/1422-0067/20/6/1299

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