Vascular Lipidomic Profiling of Potential Endogenous Fatty Acid PPAR Ligands Reveals the Coronary Artery as Major Producer of CYP450-Derived Epoxy Fatty Acids

Vascular Lipidomic Profiling of Potential Endogenous Fatty Acid PPAR Ligands Reveals the Coronary Artery as Major Producer of CYP450-Derived Epoxy Fatty Acids

A number of oxylipins have been described as endogenous PPAR ligands. The very short biological half-lives of oxylipins suggest roles as autocrine or paracrine signaling molecules. While coronary arterial atherosclerosis is the root of myocardial infarction, aortic atherosclerotic plaque formation i...

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Bibliographic Details
Main Authors: Matthew L. Edin, Fred B. Lih, Bruce D. Hammock, Scott Thomson, Darryl C. Zeldin, David Bishop-Bailey
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
PPARs
vascular
coronary artery
lipidomics
eicosanoids
inflammation
Online Access:https://www.mdpi.com/2073-4409/9/5/1096

Internet

https://www.mdpi.com/2073-4409/9/5/1096

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