A surrogate virus neutralization test to quantify antibody-mediated inhibition of SARS-CoV-2 in finger stick dried blood spot samples

Abstract The spike protein of SARS-CoV-2 engages the human angiotensin-converting enzyme 2 (ACE2) receptor to enter host cells, and neutralizing antibodies are effective at blocking this interaction to prevent infection. Widespread application of this important marker of protective immunity is limit...

Full description

Bibliographic Details
Main Authors: Amelia E. Sancilio, Richard T. D’Aquila, Elizabeth M. McNally, Matthew P. Velez, Michael G. Ison, Alexis R. Demonbreun, Thomas W. McDade
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94653-z