Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/β-Catenin Signaling

Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/β-Catenin Signaling

Summary: Aryl hydrocarbon receptor (AhR) deficiency alters tissue homeostasis. However, how AhR regulates organ maturation and differentiation remains mostly unknown. Liver differentiation entails a polyploidization process fundamental for cell growth, metabolism, and stress responses. Here, we repo...

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Bibliographic Details
Main Authors: Nuria Moreno-Marín, Jaime M. Merino, Alberto Alvarez-Barrientos, Daxeshkumar P. Patel, Shogo Takahashi, José M. González-Sancho, Pablo Gandolfo, Rosa M. Rios, Alberto Muñoz, Frank J. Gonzalez, Pedro M. Fernández-Salguero
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218300610

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http://www.sciencedirect.com/science/article/pii/S2589004218300610

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