HGF/MET Axis Induces Tumor Secretion of Tenascin-C and Promotes Stromal Rewiring in Pancreatic Cancer

HGF/MET Axis Induces Tumor Secretion of Tenascin-C and Promotes Stromal Rewiring in Pancreatic Cancer

Pancreatic ductal adenocarcinoma is an aggressive tumor characterized by the presence of an abundant stromal compartment contributing significantly to the malignant phenotype. Pancreatic stellate cells are peculiar fibroblasts present in the stroma and represent the predominant source of extracellul...

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Bibliographic Details
Main Authors: Chiara Modica, Martina Olivero, Francesca Zuppini, Melissa Milan, Cristina Basilico, Elisa Vigna
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
tumor microenvironment
hepatocyte growth factor
MET oncogene
tenascin C
metastasis
Online Access:https://www.mdpi.com/2072-6694/13/14/3519

Internet

https://www.mdpi.com/2072-6694/13/14/3519

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