Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming

Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming

Werner syndrome (WS) is a rare human autosomal recessive premature aging disorder characterized by early onset of aging-associated diseases, chromosomal instability, and cancer predisposition. The function of the DNA helicase encoded by WRN, the gene responsible for WS, has been studied extensively....

Full description

Bibliographic Details
Main Authors: Akira eShimamoto, Koutaro eYokote, Hidetoshi eTahara
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Genetics
Subjects:
Chromosomal Instability
Telomerase
reprogramming
accelerated aging
induced pluripotent stem cells (iPSCs)
Telomere dysfunction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00010/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00010/full

Similar Items