Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation

Multiple myeloma (MM) is a hematological malignancy that exhibits aberrantly high levels of proteasome activity. While treatment with the proteasome inhibitor bortezomib substantially increases overall survival of MM patients, acquired drug resistance remains the main challenge for MM treatment. Usi...

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Bibliographic Details
Main Authors: Jing Chen, Esther A. Zaal, Celia R. Berkers, Rob Ruijtenbeek, Johan Garssen, Frank A. Redegeld
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
DHA
EPA
Online Access:https://www.mdpi.com/2073-4409/10/9/2287