A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector

A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector

A novel co-polymer based on 2-hydroxypropyl-α-cyclodextrin cross-linked by low molecular weight polyethylenimine was synthesized as a gene delivery vector. The copolymer could bind and condense DNA tightly. It showed lower cytotoxicity than PEI 25kDa in SK-BR-3 cells. Transfection efficiency was...

Full description

Bibliographic Details
Main Authors: Hai Yu, Hongliang Huang, Da Li, Yang Liu, Fenping Shen, Jun Zhou, Qingqing Wang, Guping Tang
Format: Article
Language:English
Published: MDPI AG 2008-11-01
Series:International Journal of Molecular Sciences
Subjects:
Polyethylenimine
2-hydroxypropyl-α-cyclodextrin
non-viral gene delivery vector
co-polymer
Online Access:http://www.mdpi.com/1422-0067/9/11/2278/

Internet

http://www.mdpi.com/1422-0067/9/11/2278/

Similar Items