A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector
A novel co-polymer based on 2-hydroxypropyl-α-cyclodextrin cross-linked by low molecular weight polyethylenimine was synthesized as a gene delivery vector. The copolymer could bind and condense DNA tightly. It showed lower cytotoxicity than PEI 25kDa in SK-BR-3 cells. Transfection efficiency was...
Main Authors: | Hai Yu, Hongliang Huang, Da Li, Yang Liu, Fenping Shen, Jun Zhou, Qingqing Wang, Guping Tang |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2008-11-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/9/11/2278/ |
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