Using previously genotyped controls in genome-wide association studies (GWAS): application to the Stroke Genetics Network (SiGN)

Using previously genotyped controls in genome-wide association studies (GWAS): application to the Stroke Genetics Network (SiGN)

Genome-wide association studies (GWAS) are widely applied to identify susceptibility loci for a variety of diseases using genotyping arrays that interrogate known polymorphisms throughout the genome. A particular strength of GWAS is that it is unbiased with respect to specific genomic elements (e.g...

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Bibliographic Details
Main Authors: Braxton D Mitchell, Myriam eFornage, Patrick F. McArdle, Yu-Ching eCheng, Sara ePulit, Quenna eWong, Tushar eDave, Stephen R Williams, Roderick eCorriveau, Katrina eGwinn, Kimberly eDoheny, Cathy eLaurie, Stephen S Rich, Paul ede Bakker
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Genetics
Subjects:
Genome-Wide Association Study
population stratification
power
case-control study
genetic association study
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00095/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00095/full

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