Biophysical and X-ray structural studies of the (GGGTT)3GGG G-quadruplex in complex with N-methyl mesoporphyrin IX.

Biophysical and X-ray structural studies of the (GGGTT)3GGG G-quadruplex in complex with N-methyl mesoporphyrin IX.

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The G-quadruplex (GQ) is a well-studied non-canonical DNA structure formed by G-rich sequences found at telomeres and gene promoters. Biological studies suggest that GQs may play roles in regulating gene expression, DNA replication, and DNA repair. Small molecule ligands were shown to alter GQ struc...

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Bibliographic Details
Main Authors: Linda Yingqi Lin, Sawyer McCarthy, Barrett M Powell, Yanti Manurung, Irene M Xiang, William L Dean, Brad Chaires, Liliya A Yatsunyk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0241513

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https://doi.org/10.1371/journal.pone.0241513

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