Purification and Biochemical Characterization of TsMS 3 and TsMS 4: Neuropeptide-Degrading Metallopeptidases in the <i>Tityus serrulatus</i> Venom

Purification and Biochemical Characterization of TsMS 3 and TsMS 4: Neuropeptide-Degrading Metallopeptidases in the <i>Tityus serrulatus</i> Venom

Although omics studies have indicated presence of proteases on the <i>Tityus serrulatus</i> venom (TsV), little is known about the function of these molecules. The TsV contains metalloproteases that cleave a series of human neuropeptides, including the dynorphin A (1-13) and the members...

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Bibliographic Details
Main Authors: Daniela Cajado-Carvalho, Cristiane Castilho Fernandes da Silva, Roberto Tadashi Kodama, Douglas Oscar Ceolin Mariano, Daniel Carvalho Pimenta, Bruno Duzzi, Alexandre Kazuo Kuniyoshi, Fernanda Vieira Portaro
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Toxins
Subjects:
<i>Tityus serrulatus</i>
metalloserrulases
proteases
purification
biochemical characterization
neuropeptides
Online Access:https://www.mdpi.com/2072-6651/11/4/194

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https://www.mdpi.com/2072-6651/11/4/194

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