The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276

The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276

Abstract Background The links between the p53/MDM2 pathway and the expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence in the expression of two key immune receptors, CD276 and PD-L1. Methods Pro...

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Bibliographic Details
Main Authors: Ruidong Li, Pavlina Zatloukalova, Petr Muller, Maria Gil-Mir, Sachin Kote, Simon Wilkinson, Alain J. Kemp, Lenka Hernychova, Yaxin Wang, Kathryn L. Ball, Kaixiong Tao, Ted Hupp, Borivoj Vojtesek
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
MDM2
p53
Gene editing
Protein-protein interactions
Nutlin-3
Online Access:http://link.springer.com/article/10.1186/s11658-020-00233-w

Internet

http://link.springer.com/article/10.1186/s11658-020-00233-w

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