Characterization of naturally-occurring humoral immunity to AAV in sheep.

Characterization of naturally-occurring humoral immunity to AAV in sheep.

AAV vectors have shown great promise for clinical gene therapy (GT), but pre-existing human immunity against the AAV capsid often limits transduction. Thus, testing promising AAV-based GT approaches in an animal model with similar pre-existing immunity could better predict clinical outcome. Sheep ha...

Full description

Bibliographic Details
Main Authors: Joseph Tellez, Kim Van Vliet, Yu-Shan Tseng, Jonathan D Finn, Nick Tschernia, Graça Almeida-Porada, Valder R Arruda, Mavis Agbandje-McKenna, Christopher D Porada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3782463?pdf=render

Internet

http://europepmc.org/articles/PMC3782463?pdf=render

Similar Items