Structural Perspective on Revealing and Altering Molecular Functions of Genetic Variants Linked with Diseases

Structural Perspective on Revealing and Altering Molecular Functions of Genetic Variants Linked with Diseases

Structural information of biological macromolecules is crucial and necessary to deliver predictions about the effects of mutations—whether polymorphic or deleterious (i.e., disease causing), wherein, thermodynamic parameters, namely, folding and binding free energies potentially serve as e...

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Bibliographic Details
Main Authors: Yunhui Peng, Emil Alexov, Sankar Basu
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
mutations
disease-causing mutations
polymorphism
folding free energy change
binding free energy change
drug discovery
in silico screening
Online Access:https://www.mdpi.com/1422-0067/20/3/548

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https://www.mdpi.com/1422-0067/20/3/548

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