The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy.

Both DNA and histone methylation are dysregulated in the myelodysplastic syndromes (MDS). Based on preliminary data we hypothesized that dysregulated interactions of KDM2B, let-7b and EZH2 signals lead to an aberrant epigenetic landscape. Gene expression in CD34+ cells from MDS marrows was analyzed...

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Bibliographic Details
Main Authors:	Ekapun Karoopongse, Cecilia Yeung, John Byon, Aravind Ramakrishnan, Zaneta J Holman, Peter Y Z Jiang, Qiang Yu, H Joachim Deeg, A Mario Marcondes
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4166605?pdf=render

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http://europepmc.org/articles/PMC4166605?pdf=render

The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy.

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