Overexpression of Toll-Like Receptor 4 Affects Autophagy, Oxidative Stress, and Inflammatory Responses in Monocytes of Transgenic Sheep

Overexpression of Toll-Like Receptor 4 Affects Autophagy, Oxidative Stress, and Inflammatory Responses in Monocytes of Transgenic Sheep

Toll-like receptor 4 (TLR4) is a critical pattern recognition receptor that plays a critical role in the host innate immune system’s recognition of Gram-negative bacteria. Since it is the lipopolysaccharide (LPS) receptor, it links the activated inflammatory response with autophagy and oxidative str...

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Bibliographic Details
Main Authors: Sutian Wang, Xuting Song, Kunli Zhang, Shoulong Deng, Peixin Jiao, Meiyu Qi, Zhengxing Lian, Yuchang Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TLR4
autophagy
oxidative stress
inflammatory responses
transgenic animal model
p38 MAPK
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00248/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00248/full

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