Inflammatory Potential of Four Different Phases of Calcium Pyrophosphate Relies on NF-κB Activation and MAPK Pathways

Inflammatory Potential of Four Different Phases of Calcium Pyrophosphate Relies on NF-κB Activation and MAPK Pathways

Background: Calcium pyrophosphate (CPP) microcrystal deposition is associated with wide clinical phenotypes, including acute and chronic arthritis, that are interleukin 1β (IL-1β)-driven. Two CPP microcrystals, namely monoclinic and triclinic CPP dihydrates (m- and t-CPPD), have been identified in h...

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Bibliographic Details
Main Authors: Laure Campillo-Gimenez, Félix Renaudin, Maud Jalabert, Pierre Gras, Marjolaine Gosset, Christian Rey, Stéphanie Sarda, Corinne Collet, Martine Cohen-Solal, Christèle Combes, Frédéric Lioté, Hang-Korng Ea
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
CPP crystals
microcrystal-induced arthritis
IL-1β
MAP kinase signaling
NF-κB pathway
macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02248/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02248/full

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