Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment

Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment

Previous evidence links the formation of extranuclear inclusions of transcription factors, such as ERK, Jun, TDP-43, and REST, with oxidative, endoplasmic-reticulum, proteasomal, and osmotic stress. To further characterize its extranuclear location, we performed a high-content screening based on con...

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Bibliographic Details
Main Authors: Chiara Rossi, Anna Fernàndez, Pascual Torres, Omar Ramirez-Nuñez, Ana Belén Granado-Serrano, Laia Fontdevila, Mònica Povedano, Reinald Pamplona, Isidro Ferrer, Manuel Portero-Otin
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
TDP-43
Jun
REST
ERK
mitochondria
cell stress
Online Access:https://www.mdpi.com/1422-0067/22/16/8853

Internet

https://www.mdpi.com/1422-0067/22/16/8853

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