Pulmonary Neuroendocrine Neoplasms Overexpressing Epithelial-Mesenchymal Transition Mechanical Barriers Genes Lack Immune-Suppressive Response and Present an Increased Risk of Metastasis

Pulmonary Neuroendocrine Neoplasms Overexpressing Epithelial-Mesenchymal Transition Mechanical Barriers Genes Lack Immune-Suppressive Response and Present an Increased Risk of Metastasis

Typical carcinoids (TC), atypical carcinoids (AC), large cell neuroendocrine carcinomas (LCNEC), and small cell lung carcinomas (SCLC) encompass a bimodal spectrum of metastatic tumors with morphological, histological and histogenesis differences, The hierarchical structure reveals high cohesiveness...

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Bibliographic Details
Main Authors: Tabatha Gutierrez Prieto, Camila Machado Baldavira, Juliana Machado-Rugolo, Cecília Farhat, Eloisa Helena Ribeiro Olivieri, Vanessa Karen de Sá, Eduardo Caetano Abilio da Silva, Marcelo Luiz Balancin, Alexandre Muxfeldt Ab´Saber, Teresa Yae Takagaki, Vladmir Cláudio Cordeiro de Lima, Vera Luiza Capelozzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
pulmonary neuroendocrine neoplasms
epithelial to mesenchymal transition transcriptional factors
desmosomes
desmocollin
collagen
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.645623/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.645623/full

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