Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation

Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation

Objective: Lysine acetylation is an important post-translational modification that regulates metabolic function in skeletal muscle. The acetyltransferase, general control of amino acid synthesis 5 (GCN5), has been proposed as a regulator of mitochondrial biogenesis via its inhibitory action on perox...

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Bibliographic Details
Main Authors: Jessica R. Dent, Vitor F. Martins, Kristoffer Svensson, Samuel A. LaBarge, Noah C. Schlenk, Mary C. Esparza, Elisa H. Buckner, Gretchen A. Meyer, D. Lee. Hamilton, Simon Schenk, Andrew Philp
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817306968

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http://www.sciencedirect.com/science/article/pii/S2212877817306968

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