High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-<i>N</i>-acyl-β-<span style="font-variant: small-caps">d</span>-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors

High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-<i>N</i>-acyl-β-<span style="font-variant: small-caps">d</span>-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors

Structure-based design and synthesis of two biphenyl-<i>N</i>-acyl-&#946;-<span style="font-variant: small-caps;">d</span>-glucopyranosylamine derivatives as well as their assessment as inhibitors of human liver glycogen phosphorylase (hlGPa, a pharmaceutical ta...

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Bibliographic Details
Main Authors: Thomas Fischer, Symeon M. Koulas, Anastasia S. Tsagkarakou, Efthimios Kyriakis, George A. Stravodimos, Vassiliki T. Skamnaki, Panagiota G.V. Liggri, Spyros E. Zographos, Rainer Riedl, Demetres D. Leonidas
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
structure-based design
glycogen phosphorylase inhibitor
glycogen metabolism
type 2 diabetes
X-ray crystallography
<i>N</i>-acyl-β-<span style="font-variant: small-caps">d</span>-glucopyranosylamine
Online Access:https://www.mdpi.com/1420-3049/24/7/1322

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https://www.mdpi.com/1420-3049/24/7/1322

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