Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases.

Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases.

DNA methylation is an epigenetic modification that plays a crucial role in normal mammalian development, retrotransposon silencing, and cellular reprogramming. Although methylation mainly occurs on the cytosine in a CG site, non-CG methylation is prevalent in pluripotent stem cells, brain, and oocyt...

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Bibliographic Details
Main Authors: Kenjiro Shirane, Hidehiro Toh, Hisato Kobayashi, Fumihito Miura, Hatsune Chiba, Takashi Ito, Tomohiro Kono, Hiroyuki Sasaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3630097?pdf=render

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http://europepmc.org/articles/PMC3630097?pdf=render

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