High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections

High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections

Abstract Background The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces the activation of the kynurenine pathway (KP) with the production of...

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Bibliographic Details
Main Authors: Else Quist-Paulsen, Pål Aukrust, Anne-Marte Bakken Kran, Oona Dunlop, Vidar Ormaasen, Birgitte Stiksrud, Øivind Midttun, Thor Ueland, Per Magne Ueland, Tom Eirik Mollnes, Anne Ma Dyrhol-Riise
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Neuroinflammation
Subjects:
Encephalitis
Aseptic meningitis
Bacterial meningitis
Cytokines
Chemokines
Kynurenine tryptophan pathway
Online Access:http://link.springer.com/article/10.1186/s12974-018-1366-3

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http://link.springer.com/article/10.1186/s12974-018-1366-3

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