TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal Tumorigenesis

TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal Tumorigenesis

The short isoform of human TIAM2 has been shown to promote proliferation and invasion in various cancer cells. However, the roles of TIAM2S in immune cells in relation to tumor development have not been investigated. To characterize the effects of TIAM2S, we generated TIAM2S-overexpressing mouse lin...

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Bibliographic Details
Main Authors: Ya-Ling Chan, Wei-Chung Lai, Jia-Shing Chen, Joseph Ta-Chien Tseng, Pei-Chin Chuang, Jonathan Jou, Chung-Ta Lee, H. Sunny Sun
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
T-cell lymphoma invasion and metastasis 2
chronic inflammation
serotonin
T lymphocyte
inflammatory bowel disease
Online Access:https://www.mdpi.com/2072-6694/12/7/1844

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https://www.mdpi.com/2072-6694/12/7/1844

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