Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor

Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor

Citrullination, a posttranslational modification, is catalyzed by peptidylarginine deiminases (PADs), a unique family of enzymes that converts peptidyl-arginine to peptidyl-citrulline. Overexpression and/or increased PAD activity is observed in rheumatoid arthritis (RA), Alzheimer’s diseas...

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Bibliographic Details
Main Authors: Ardita Aliko, Marta Kamińska, Katherine Falkowski, Ewa Bielecka, Malgorzata Benedyk-Machaczka, Stanisław Malicki, Joanna Kozieł, Alicia Wong, Danuta Bryzek, Tomasz Kantyka, Piotr Mydel
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
PAD4
inhibitor
citrullination
rheumatoid arthritis
PPAD
NETs
Online Access:https://www.mdpi.com/1422-0067/20/9/2174

Internet

https://www.mdpi.com/1422-0067/20/9/2174

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