Early Developmental Zebrafish Embryo Extract to Modulate Senescence in Multisource Human Mesenchymal Stem Cells

Early Developmental Zebrafish Embryo Extract to Modulate Senescence in Multisource Human Mesenchymal Stem Cells

Stem cells undergo senescence both in vivo, contributing to the progressive decline in self-healing mechanisms, and in vitro during prolonged expansion. Here, we show that an early developmental zebrafish embryo extract (ZF1) could act as a modulator of senescence in human mesenchymal stem cells (hM...

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Bibliographic Details
Main Authors: Federica Facchin, Francesco Alviano, Silvia Canaider, Eva Bianconi, Martina Rossi, Laura Bonsi, Raffaella Casadei, Pier Mario Biava, Carlo Ventura
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
stem cells
senescence
zebrafish embryo extract
senescence-associated β-galactosidase activity
adipogenesis
<i>TERT</i>
<i>BMI1</i>
<i>p53</i>
<i>p21</i>
<i>p16</i>
Online Access:https://www.mdpi.com/1422-0067/20/11/2646

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https://www.mdpi.com/1422-0067/20/11/2646

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