Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization

Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization

HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. Analysis of Hp1α−/−, Hp1β−/−, and Hp1γ−/− MEFs show that HP1 proteins have both redundant and unique...

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Bibliographic Details
Main Authors: Laia Bosch-Presegué, Helena Raurell-Vila, Joshua K. Thackray, Jessica González, Carmen Casal, Noriko Kane-Goldsmith, Miguel Vizoso, Jeremy P. Brown, Antonio Gómez, Juan Ausió, Timo Zimmermann, Manel Esteller, Gunnar Schotta, Prim B. Singh, Lourdes Serrano, Alejandro Vaquero
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
heterochromatin
HP1α
HP1β
HP1γ
Suv420h2
H4K20me3
genome organization
genome stability
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717315723

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http://www.sciencedirect.com/science/article/pii/S2211124717315723

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