Role of Phosphatidylinositol 3-Kinase (PI3K), Mitogen-Activated Protein Kinase (MAPK), and Protein Kinase C (PKC) in Calcium Signaling Pathways Linked to the α1-Adrenoceptor in Resistance Arteries

Role of Phosphatidylinositol 3-Kinase (PI3K), Mitogen-Activated Protein Kinase (MAPK), and Protein Kinase C (PKC) in Calcium Signaling Pathways Linked to the α1-Adrenoceptor in Resistance Arteries

Insulin resistance plays a key role in the pathogenesis of type 2 diabetes and is also related to other health problems like obesity, hypertension, and metabolic syndrome. Imbalance between insulin vascular actions via the phosphatidylinositol 3-Kinase (PI3K) and the mitogen activated protein kinase...

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Bibliographic Details
Main Authors: Alejandro Gutiérrez, Cristina Contreras, Ana Sánchez, Dolores Prieto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Physiology
Subjects:
ERK-MAPK
PI3K
PKC
L-type Ca2+ channel
RyR
intracellular Ca2+ mobilization
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00055/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00055/full

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